Frequently Asked Questions

Brain Ritual® is a unique holistic medical food containing antioxidants and most micro-and macro-nutrients necessary for energy production, including bioactive, human identical ketone bodies, the brain’s preferred fuel source. It is specifically formulated to meet the nutritional requirements of migraine sufferers and to compensate for the dysfunctional brain energy metabolism which can be a root of migraine attacks that cannot be addressed through diet modification alone.

Store in a dry place at room temperature away from heat, light, and moisture.

More and more research suggests that migraine is, at least partially, an energy deficiency syndrome and a migraine attack may be a signal for low energy in the brain. On a carbohydrate rich diet the brain’s primary source of energy is glucose. However, we know that ketone bodies can serve as a cleaner and more efficient fuel for the brain. Brain Ritual® is made with ketone bodies, in addition to vital nutrients and antioxidants that support the entire process of energy metabolism and through that, manage migraine. This is difficult to achieve through dietary modifications alone.

Brain Ritual® is formulated with high quality, bioactive ingredients including a mixture of exogenous ketone bodies, vitamins (fat and water-soluble), minerals, trace minerals, ketogenic and other amino acids, antioxidants, such as CoQ10 without artificial flavoring or synthetic coloring. 

Brain Ritual® Ingredients List

The science behind Brain Ritual® originated in Switzerland, where we developed our product. It is manufactured in the US with globally sourced ingredients for the highest quality and efficacy. Brain Ritual® is manufactured in a cGMP (current Good Manufacturing Practices) facility which is registered with the FDA and follows the required codes of CRF 110, 111 and 117. Additionally, we conduct strict quality controls of partner labs throughout the process.

Brain Ritual® is neither a supplement nor a drug–as a medical food, it is a product specifically formulated to meet the nutritional requirements of migraine patients. What does that mean? Unlike most supplements, we use only bioactive ingredients which can be absorbed and used by your body without the need for activation or break down. Many of our ingredients have been clinically tested in migraine. Unlike drugs, Brain Ritual® contains only ingredients which are generally considered safe, without major side effects.

In case you want to make more informed decision, you can read the science behind migraine and how Brain Ritual® addresses this issue.Additionally, you can learn more by visiting our social media channels and our blog.

Brain Ritual® is designed to support your metabolism and address your nutritional needs and can be taken long-term.

Metabolism can be a root cause of migraine, but not in all cases. It’s an extremely heterogeneous disorder and there is no “one-size-fits-all” solution. Approximately half of migraine sufferers might have suboptimal metabolism contributing to migraine, but it is still early to give an exact percentage here.

Yes, Brain Ritual® supports overall brain health. It is designed to nourish the brain with essential nutrients that enhance energy metabolism and performance. Its comprehensive blend of bioactive vitamins, minerals, and other bio-active ingredients not only targets migraines but also promotes overall brain health. Ingredients such as Coenzyme Q-10, L-Carnitine, and D-Beta-Hydroxybutyrate enhance mitochondrial efficiency and energy production, while antioxidants and electrolytes support brain function and hydration. This makes Brain Ritual® beneficial not only for managing migraine but also for improving overall brain health and performance.

Brain Ritual® primarily focuses on nourishing the brain with essential nutrients and supporting energy metabolism, which may help manage various migraine symptoms, including auras. The blend of vitamins, minerals, and other bio-active ingredients in Brain Ritual® works synergistically to enhance overall brain performance. However, it is essential to consult with a healthcare professional to determine the most suitable approach for managing your migraine, including auras.

Brain Ritual® addresses nutritional deficiencies linked to migraines through a blend of vitamins, minerals, and bio-active ingredients. This combination supports brain health and energy metabolism, targeting migraine symptoms like headache intensity and frequency. Vitamins A, C, D, E, K, and a comprehensive B-vitamin complex offer antioxidant protection and energy production support. Essential minerals like magnesium, calcium, and zinc aid cellular hydration and enzyme function. Coenzyme Q-10, L-Carnitine, and D-Beta-Hydroxybutyrate enhance mitochondrial efficiency and energy production. This comprehensive approach is backed by Swiss science.

The optimal dosage for best results is 2 servings per day (1 morning, 1 afternoon), which is 60 servings per month. However, we suggest gradually working up to the optimal 2 daily servings to ease your digestive system into the high nutrient load.

Dissolve a sachet in cold or room temperature water, tea (not hot) or other beverage, adjust to taste (we recommend around 16 oz) and enjoy! You can also add ice cubes or use sparkling water, juice or other cold beverages. In the first week, in order to adapt to Brain Ritual®'s high nutrient load, please take half a sachet twice a day, morning and afternoon. Thereafter, take a full sachet 2 times a day (morning & afternoon). Ideally take it with or after food or sip throughout the day, especially, if you experience any gastrointestinal upset. This will help decrease mineral load on an empty stomach. If gastrointestinal upset persists, please half your dose. Do not take in addition to general multi-vitamin unless advised by your medical professional. Use under medical supervision.

You should notice initial changes within 3-4 weeks, sooner for some people. While it might take longer for some, if you don’t notice any results after taking Brain Ritual® twice a day for 4 weeks as intended, metabolism may not be a major contributing factor to your migraine.

Do not use Brain Ritual® if you suffer from type 1 Diabetes, severe kidney disease, rare inborn disorders of fat metabolism or any hypersensitivities or allergies to the ingredients contained in this product. Consider recommended upper daily limits when taking additional supplements or refrain from using a broad spectrum multivitamin. Consult your physician on dosage for children under the age of 16 or when planning or being pregnant.

Many of the nutrients contained in Brain Ritual® are also part of a prenatal formulation and ketone bodies are important for a baby's brain development. However, due to Brain Ritual® being a medical food for migraine, some nutrients such as riboflavin come in very high doses and this had not have been studied in pregnant women. Please consult with your medical doctor before usingBrain Ritual® during pregnancy or lactation.

Brain Ritual® is a medical food. Medical foods, being neither drugs nor supplements, are defined insection 5(b) of the Orphan Drug Act (21 U.S.C. 360ee (b) (3)) and are regulated by the US Food and Drug Administration (FDA). They fall under the same strict requirements as food production and must consist of ingredients which are generally recognized as safe. Similar to supplements, there is no pre-market approval.

The main active ingredient of Brain Ritual® is patented for use in migraine under U.S. Pat.No. 11,166,928.

Yes, it is. 

Yes, Brain Ritual® is gluten-free, dairy-free, low carb (≤1g), and suitable for vegans. It does not contain any artificial flavors or synthetic colorings.

All ingredients are non-GMO. However one of our non-GMO sweeteners is fermented with bacteria that is genetically modified, but completely removed from the final product.

Yes, Brain Ritual® is keto-friendly. It's developed to support brain health and migraine management, aligning with the principles of a ketogenic diet. Brain Ritual® contains ingredients like D-Beta-Hydroxybutyrate (as R-3-Hydroxybutyric Acid Calcium Magnesium Salts), which is the most abundant ketone body that a body produces during a ketogenic diet.

There are no major systemic side effects. Minor side effects may include gastrointestinal distress, due to high mineral and nutrient load. Please start with half a sachet twice a day in the first week of Brain Ritual, to allow for some adaptation. Should you still experience GI distress, try taking Brain Ritual® after a meal or sip it throughout the day to reduce the mineral load on an empty stomach and if persistent please reduce the dose by half. The B vitamins in Brain Ritual® may turn your urine yellow, this is harmless. Always check with your medical professional, if you are experiencing any side effects.

Yes, people with chronic migraines can use Brain Ritual® long-term. Brain Ritual® is designed with a focus on addressing nutritional deficiencies linked to migraines and supporting overall brain health, making it suitable for ongoing use. Unlike many migraine drugs, Brain Ritual® has no systemic side effects, making it a safer option for long-term management.

We recommend a low-carb or low glycemic index diet consisting of whole foods. This may further help in managing your migraine. However, dietary modification is not necessary when taking Brain Ritual®.

Brain Ritual® is orange-flavored (with other natural flavors). However, we’re already working on future flavors.

Brain Ritual® has no added sugar and contains less than ≤1g of carbohydrates.

Since Brain Ritual® already has many vitamins and minerals (including high doses of those key for migraine management, such as B2), any combination with a supplement should be consulted with your doctor.

Diarrhea and gastrointestinal upset may occur due to the high mineral and nutrient load in Brain Ritual®.To reduce digestive issues, try taking it after a meal or sip it throughout the day. Please also start with a smaller dose, such as half or a third of a sachet, and gradually increase it.If GI discomfort persists, reduce the dose by half. Always consult a medical professional if you experience any side effects

Please consult your medical professional prior to adding Brain Ritual® to your daily regimen as it has to be taken under medical supervision. On a ketogenic diet, topiramate (Topamax or other) is a contra-indication. As Brain Ritual® contains ketone bodies, it should not be used conjointly with topiramate-containing drugs. Please take at least 30 mins away from any thyroid medication. Please do not use with a general multi-vitamin formulation, unless advised by your medical professional. Do not take together with any medication that cannot be taken with the minerals, vitamins, amino acids, ketone bodies or other ingredients contained in Brain Ritual®.

You do not need a prescription, however Brain Ritual® has to be used under medical supervision.

Unfortunately, Brain Ritual® is not yet covered by health insurance. You can speak to your physician about a certificate of medical necessity, which would allow you to reimburse it out of your HSA or FSA account.

As long as the order has not yet been fulfilled, you have the option to cancel.

Full payment is due at checkout. As long as the order has not yet been fulfilled, you have the option to cancel. Once the order has been fulfilled, it cannot be canceled but full or partial refund may be requested. No products may be returned for credit or refund without prior authorization from Brain Ritual®. Customer will be responsible for all shipping charges for any returned products. Expired products may not be returned under any circumstances. Brain Ritual® is not liable for replacement of products that have been damaged by any party outside of Brain Ritual®’s control.The product must be unused and unopened, and returned within 30 days of the order date. Please allow up to 2 weeks to process after your return is received by our warehouse, to receive a refund to your original form of payment.

Once your order has shipped, you will receive a confirmation email with tracking information.

You will be emailed tracking information. If you have a Brain Ritual® account, you can also check for details there.

Brain Ritual® currently only ships within the US and Canada - we are working to make international shipping available as soon as possible!

We accept all major credit cards, Shop Pay, Google Pay, Apple Pay and Meta Pay.

We are sorry to hear there was an issue with your order! Please contact our team at info@brainritual.com for any replacement requests and we would be happy to assist.

As discussed in detail above, one of the most consistently reported changes in migraine is abnormal energy metabolism. Therefore, migraineurs seem to have distinct metabolic and nutrient requirements for an additional and more efficient energy source and/or improved energy production overall.

The specific nutritional and metabolic requirements of migraineurs cannot be met with simple adaptations of a normal diet.Firstly, the levels of many key ingredients of Brain Ritual® such as magnesium and riboflavin are specifically designed to meet the unique requirements of migraine sufferers and are not achievable through a normal diet.Furthermore, while ketosis can be achieved via a ketogenic diet, it is hard to maintain in the long term and sufferers that have over consumed analgesics for decades can struggle with liver function – the primary place of ketone bodies’ A ketogenic diet is based on very limited carbohydrate and moderate protein intake with a simultaneous increase in fat consumption, which imitates some aspects of fasting and resets the body to lipid-based metabolism, i.e. obtaining ketone bodies through FAO (fatty acid oxidation) in the liver. A strict ketogenic diet usually results in values around 2 mmol/l – with nutritional ketosis beginning at 0.5mM (Poff et al., 2020). However, there may be side effects and some risks it entails long-term (Kossoff et al., 2018), as it requires a drastic reduction of foods such as fruits and colorful vegetables, which are generally considerd as healthy. These include gastrointestinal problems, increase in blood cholesterol, deficiencies in minerals and other nutrients, and – on a psychological level – social constraints. Constant fasting and/or strict ketogenic diet (to the extent of reaching therapeutic levels of ketosis meaning under 20g of carbs per day) is extremely hard to sustain long-term and adherence is one of the main problems (Maalouf et al., 2009) and it can hardly be considered an adaptation of normal diet. Moreover, if not monitored properly it can result in other complications such as kidney stones (Sampath et al., 2007) or increase in blood cholesterol (Gross et al., 2019).Therefore, bioidentical exogenous ketone bodies, in the form of D-beta-hydroxybutyrate (D-BHB) mineral salts, in addition to various micronutrients and antioxidants that have been shown to be beneficial in migraine, could provide a feasible alternative with improved compliance due to no demanding lifestyle changes and lack of other potential complications described above. Exogenous ketone bodies are those which are not produced by your body, but produced in the lab and delivered in a form of e.g. a powder, as in Brain Ritual®. They have the same chemical structure as the one produced by the liver and are known to be absorbed by the body and – depending on the type – metabolized in the liver or directly enter the blood circulation (Plecko et al., 2002). They can include only the active, D-BHB isomer, which makes them even more tolerable and effective than the racemic versions (Soto-Mota et al., 2020; Stubbs et al., 2017). This is the form of BHB used in Brain Ritual®. Studies have shown that exogenous supplementation can cause a rapid and sustained elevation of BHB (Kesl et al., 2016).

Medical foods are neither drugs nor supplements – they are specially formulated and processed products for dietary management of diseases with a metabolic component. They are taken orally and aimed for sufferers with limited or impaired capacity to ingest, digest, absorb or metabolize ordinary foodstuff or certain nutrients and a resulting special nutrient or metabolic requirements. These requirements cannot be achieved by a modification of a normal diet alone. They were defined in the Orphan Drug Act (21 USC 360ee(b)(3)) and are regulated by the 21 CFR 101.9(j)(8) and have to be used under medical supervision.

Migraine is the most common neurological disease, with about 1 billion sufferers across the world, out of which there are twice as many women than men (Stovner et al., 2018). It’s also the 2nd biggest cause of disability in the world and 1st among young women (Steiner et al., 2020). While its pathophysiology is not clear, hypoglycemia has been associated with migraine for almost a century (Gray & Burtness, 1935) and its symptoms (such as dizziness, pale skin, nausea, low blood pressure, tiredness, sugar cravings, cognitive difficulties) bear striking resemblance to those associated with migraine, particularly in the premonitory phase (Binder & Bendtson, 1992). A large number of studies in migraine point towards a variety of different metabolic abnormalities, and in fact, one of the most consistently reported changes in migraine is energy metabolism, including mitochondrial dysfunction (S. Ashina et al., 2021) and higher fasting glucose levels (Cavestro et al., 2007; Gross, Lisicki, et al., 2019; Siva et al., 2018). Hypothalamus (controlling homeostasis) is known to be activated early on during migraine attacks (Denuelle et al., 2007; Maniyar et al., 2014; Schulte et al., 2016). Moreover, dysfunctional metabolic responses have been observed after GTT in several studies of sufferers with migraine (Shaw et al., 1997), as have been interictal impairments of glucose tolerance (Cavestro et al., 2007; Dexter et al., 1978). These various abnormalities in combination with unfavourable environmental factors can lead to a higher energy expenditure than supply and might determine disease severity.

As described above, migraine can be considered a metabolic disorder and as a consequence, migraineurs have specific metabolic and nutritional requirements, which include a need for an additional and more efficient energy source, and support alongside the energy production process.Brain Ritual® is specifically formulated so that it meets exactly those needs. It is designed to boost brain’s metabolism and therefore manage migraine via a nutrition route as it contains most micro- and macro-nutrients necessary for energy production. This includes the bioactive form of ketone bodies (D-BHB) - the brain’s preferred fuel source and other co-factors and enzymes key in energy production, such as magnesium, riboflavin, L-carnitine and coenzyme Q10 (explained in question above). Many of its ingredients have also been studied in migraine clinical trials (see reference list in question below). The increase in energy production caused by the ketone bodies together with other ingredients of Brain Ritual® can counterbalance the dysfunctional metabolism which might be the root cause of migraine attacks and provides a way to dietary manage the disease.

Many ingredients of Brain Ritual® have been evaluated in clinical migraine studies and the key ingredient is patented by us for use in migraine. Please refer to the scientific literature below:U.S. Patent No. 11,166,928 „Migraine Prevention and Treatment”Gross, et al., Defining metabolic migraine with a distinct subgroup of sufferers with suboptimal inflammatory and metabolic markers (2023). Scientific Reports, 13(1), 3787.Hajihashemi, et al., The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo- controlled, double-blind trial, Cephalalgia (2019). Ghorbani, et al., Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial, Neurological Sciences (2020).Schoenen, et al., Effectiveness of high-dose riboflavin in migraine prophylaxis, American Academy of Neurology (1998). Peikert, et al., Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study, Cephalalgia (1996). Kӧseoglu, et al., The effects of magnesium prophylaxis in migraine without aura, Magnesium Research (2008). Rozen, et al., Open label trial of coenzyme Q10 as a migraine preventive, Cephalalgia (2002). Shoeibi, et al., Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial, Belgian Neurological Society (2016). Karimi, et al., The efficacy of magnesium oxide and sodium valproate in prevention of migraine headache: a randomized, controlled, double-blind, crossover study, Belgian Neurological Society (2019).Boehnke, et al., High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre, European Journal of Neurology (2004). Rahimdel, et al., Effectiveness of Vitamin B2 versus Sodium Valproate in Migraine Prophylaxis: a randomized clinical trial, Electronic Physician (2008) For a references list please click here